产品货号：
Z17220
中文名称：
GLI3抗体
英文名称：
Anti-GLI3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GLI3 Antibody |
| 指标别名 | ACLS;GCPS;GLI family zinc finger 3;GLI3;PAP A;PAPA;PAPA1;PAPB;PHS;PPDIV;Zinc finger protein GLI3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | GLI3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Gli3(40-57aa SNEDESPGQTYHRERRNA),different from the related rat sequence by two amino acids,and from the related mouse sequence by one amino acid. |
| 实际分子量 | 170KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | GLI3(Gli-kruppel family member 3),also called ONCOGENE GLI3,encodes a member of the zinc finger gene family related to Kruppel,a gene that is known to regulate development in Drosophila.The GLI3 gene is expressed as an 8.5-kb mRNA in tissues such as testis,myometrium,placenta,and lung,and the protein product(relative molecular mass,190,000) shows sequence-specific DNA binding.The GLI3 gene is mapped on 7p14.1.GLI3 is homologous to the Drosophila cubitus interruptus(ci) gene product(Ci),which regulates the Patched(pct),gooseberry(gsb),and decapentaplegic(dpp) genes.PKA-dependent processing of vertebrate GLI3 in developing limb generates a potent repressor in a manner antagonized by apparent long-range signaling from posteriorly localized Sonic hedgehog protein.The high relative abundance and potency of GLI3 repressor suggested specialization of GLI3 and its products for negative hedgehog pathway regulation.Coimmunoprecipitation and immunoblot studies showed that GLI3 protein is polyubiquitinated and that its processing depends on proteasome activity.The findings suggested that BTRC is required for GLI3 processing. |
| Uniprot ID | P10071 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | GLI family zinc finger 3 |
| 蛋白名全称 | Transcriptional activator GLI3 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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